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2014


Ishida J, Hinou H, Naruchi K, Nishimura S.-I., (2014) Synthesis of neoglycophingolipids from methoxyamino-functionalized ceramide. Bioorganic Medicianl Chemistry Letters. 24, 1197-1200.
Matsushita T, Takada W, Igarashi K, Naruchi K, Garcia-Martin F, Amano M, Hinou H, Nishimura S.-I., (2014) A straightforward protocol for the preparation of high performance microarray displaying synthetic MUC1 glycopeptides. BBA-General Subject. 1840, 1105-1116.
Marcelo F, Garcia-Martin F, Matsuhsita M, Sardinha J, Coelho H, Qude-Vrielink A, Sabine Andre C. K., Cabrita E. J., Gabius H-J., Nishimura S-I., Jimenez-Barbero J., and F. Javier Canada, (2014) Delineating binding modes of Gal/GalNAc and structural elements of the molecular recognition of tumor-associated mucin glycopeptides by the human macrophage galactose-type lectin. Chem. Euro. J. 20, 16147-16155.
Garcia-Martin F, Matsushita T, Hinou H, Nishimura S-I., (2014) Fast epitope mapping for the anti-MUC1 monoclonal antibody by combining one-bead-one-glycopeptide library and microarray platform. Chem. Eur. J. 20, 15891-15902.
Amano M, Hinou H, Miyoshi R, Nishimura S-I., (2014) Potential Usage for In Vivo Lectin Screening in Live Animals Utilizing Cell Surface Mimetic Glyco- nanoparticles, Phosphorylcholine-Coated Quantum Dots (PC-QDs) Lectins: Methods and Prorocols, Methods Mol Biol. Vol.1200, Cap.31, 361-369.
Shinohara Y, Furukawa J, (2014) Surface plasmon resonance as a tool to characterize lectin-carbohydrate interactions. In Lectins (Methods in Molecular Biology) Hirabayashi J.(Ed) Humana Press/Springer, 1200:185-205.
Ito K, Furukawa J, Yamada K, Tran NL, Shinohara Y, Izui S, (2014) Lack of Galactosylation Enhances the Pathogenic Activity of IgG1, but not IgG2a Anti-erythrocyte Autoantibodies. J. Immunol. 192, 581-588.
Sasazawa F, Onodera T, Yamashita T, Seito N, Tsukuda Y, Fujitani N, Shinohara Y, Iwasaki N, (2014) Depletion of Gangliosides Enhances Cartilage Degradation in Mice. Osteoarthritis Cartilage, 22, 313-322.
Hanamatsu H, Ohnishi S, Sakai S, Yuyama K, Mitsutake S, Takeda H, Hashino S, Igarashi Y, (2014) Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults. Nutr. Diabetes. 4:e141.
Yuyama K, Sun H, Sakai S, Mitsutake S, Okada M, Tahara H, Furukawa JI, Fujitani N, Shinohara Y, Igarashi Y, (2014) Decreased Amyloid-β Pathologies by Intracerebral Loading of Glycosphingolipid-enriched Exosomes in Alzheimer Model Mice. J. Biol. Chem. 289(35):24488-98.
Arisawa M, Sato T, Hoshiy N, Al-Amin M, Kogami Y, Shuto S, (2014) Ligand-free Suzuki-Miyaura Coupling with Sulfur-modified Gold-supported Palladium in the Synthesis of a Conformationally-Restricted Cyclopropane Compound Library with Three-Dimensional Diversity. ACS Comb. Sci. 16(5):215-20.
Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S, (2014) Structurally novel highly potent proteasome inhibitors created by the dtructure-nased hybridization of non-peptidic belactosin derivatives and peptide boronates. J. Med. Chem. 57, 2726-2735.
Kawamura S, Unno Y, Hirokawa T, Asai A, Arisawa M, Shuto S, (2014) Rational hopping of a peptidic scaffold into non-peptidic scaffolds: structurally novel potent proteasome inhibitors derived from a natural product, belactosin A. Chem. Commun. 50, 2445-2447.
Kawamura S, Unno Y, Asai A, Arisawa M, Shuto S, (2014) Development of a New Class of Proteasome Inhibitors with an Epoxyketone Warhead: Rational Hybridization of Non-Peptidic Belactosin Derivatives and Peptide Epoxyketones. Bioorg. Med. Chem. 22, 3091-3095.
Sassa T, Wakashima T, Ohno Y, Kihara A, (2014) Lorenzo’s oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid. J Lipid Res, 55(3):524-30.
Sassa T, Kihara A, (2014) Metabolism of very long-chain fatty acids: genes and pathophysiology. Biomol Ther, 22:83-92.
Onodera Y, Nam JM, Bissell MJ. (2014) Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 124(1):367-84.
Takeoka Y, Tanino T, Sekiguchi M, Yonezawa S, Sakagami M, Takahashi F, Togame H, Tanaka Y, Takemoto H, Ichikawa S, Matsuda A, (2014) Expansion of antibacterial spectrum of muraymycins toward Pseudomonas aeruginosa. ACS Med Chem Lett. 5(5):556-60.
Kanda A, Ishida S, (2014) Roles of the retinal pigment epithelium in neuroprotection. Neuroprotection and Regeneration for Retinal Diseases. Eds: Nakazawa T & Harada T, Springer. 227-238.
Ishizuka ET, Kanda A, Kase S, Noda K, Ishida S, (2014) Involvement of the Receptor-Associated Prorenin System in the Pathogenesis of Human Conjunctival Lymphoma. Invest Ophthalmol Vis Sci. 56:74-80.
Kodama M, Yoshida R, Hasegawa T, Izawa M, Kitano M, Baba K, Noshi T, Seki T, Okazaki K, Tsuji M, Kanazu T, Kamimori H, Homma T, Kobayashi M, Sakoda Y, Kida H, Sato A, Yamano Y, (2014) The relationship between in vivo antiviral activity and pharmacokinetic parameters of peramivir in influenza virus infection model in mice. Antiviral Res. 109,110-115.
Matsui T, Han X, Yu J, Yao M, Tanaka I, (2014) Structural Change in FtsZ Induced by Intermolecular Interactions between Bound GTP and the T7 Loop. J Biol Chem. 289(6):3501-9.
Yamashita D, Sugawara T, Takeshita M, Kaneko J, Kamio Y, Tanaka I, Tanaka Y, Yao M, (2014) Molecular basis of transmembrane beta-barrel formation of staphylococcal pore-forming toxins. Nat. Commun. 5: 4897.
Liu Y, Nakamura A, Nakazawa Y, Asano N, Ford K-A, Hohn M-J, Tanaka I, Yao M, Söll D, (2014) Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea. Proc. Natl. Acad. Sci. USA. 111: 10520-10525.
Yu J, Ogata D, Gai Z-Q, Taguchi S, Tanaka I, Ooi T, Yao M, (2014) Structures of AzrA and of AzrC complexed with substrate or inhibitor: insight into substrate specificity and catalytic mechanism. Acta Cryst. D. 70: 553-564.
Fujiwara T, Saburi W, Matsui H, Mori H, Yao M, (2014) Structural Insights into the Epimerization of beta-1,4-Linked Oligosaccharides Catalyzed by Cellobiose 2-Epimerase, the Sole Enzyme Epimerizing Non-anomeric Hydroxyl Groups of Unmodified Sugars. J. Biol. Chem. 289: 3405-3415.
Srisucharitpanit K, Yao M, Promdonkoy B, Chimnaronk S, Tanaka I, Boonserm P, (2014) Crystal structure of BinB: A receptor binding component of the binary toxin from Lysinibacillus sphaericus. Proteins. 82: 2703-2712.
Asano N, Atsuumi H, Nakamura A, Tanaka Y, Tanaka I, Yao M, (2014) Direct interaction between EFL1 and SBDS is mediated by an intrinsically disordered insertion domain. Biochem. Biophys. Res. Commun. 443: 1251-1256.
Suzuki T, Yamashita K, Tanaka Y, Tanaka I, Yao M, (2014) Crystallization and preliminary X-ray crystallographic analysis of a bacterial Asn-transamidosome. Acta Cryst. F. 70: 790-793.
Shen X, Saburi W, Gai Z-Q, Komoda K, Yu J, Ojima-Kato T, Kido Y, Matsui H, Mori H, Yao M, (2014) Crystallization and preliminary X-ray crystallographic analysis of alpha-glucosidase HaG from Halomonas sp. strain H11. Acta Cryst. F. 70: 464-466.
Zheng A, Yamamoto R, Ose T, Yu J, Tanaka I, Yao M, (2014) X-ray structures of eIF5B and the eIF5B-eIF1A complex: the conformational flexibility of eIF5B is restricted on the ribosome by interaction with eIF1A. Acta Cryst. D, 1;70(Pt 12):3090-8.
Shinoda A, Tanaka Y, Yao M, Tanaka I, (2014) Anchoring protein crystals to mounting loops with hydrogel using inkjet technology. Acta Cryst. D, 70(Pt 11):2794-9.
Hayashi T, Tanaka Y, Sakai N, Okada U, Yao M, Watanabe N, Tamura T, Tanaka I, (2014) Structural and genomic DNA analysis of the putative TetR transcriptional repressor SCO7518 from Streptomyces coelicolor A3(2). FEBS Lett., 28;588(23):4311-8.
Ito K, Honda T, Suzuki T, Miyoshi T, Murakami R, Yao M, Uchiumi T, (2014) Molecular insights into the interaction of the ribosomal stalk protein with elongation factor 1α. Nucl. Acid Res. 42: 14042-52.
Asano N, Nakamura A, Komoda K, Kato K, Tanaka I, Yao M, (2014) Crystallization and preliminary X-ray crystallographic analysis of ribosome assembly factors: the Rpf2-Rrs1 complex. Acta Cryst. F70: 1649-52.
Ito S, Horikawa S, Suzuki T, Kawauchi H, Tanaka Y, Suzuki T, Suzuki T, (2014) Human NAT10 Is an ATP-dependent RNA Acetyltransferase Responsible for N4-Acetylcytidine Formation in 18S RIbosomal RNA (rRNA). J. Biol. Chem. 289: 35724-30.
Natsubori A , Honma K and Honma S, (2014) Dual regulation of clock gene Per2 expressions in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats. Eur J Neurosci, 39:229-240.
Kon N, Yoshikawa T, Honma S, Yamagata Y, Hara C, Shimizu K, Sugiyama Y, Yoshitane H, Kameshita I, Honma K and Fukada Y, (2014) CaMKII is Essential for cellular clock and coupling between morning and evening behavioral rhythms. Genes Dev. 28:1101-1110.
Ono D, Honma S, and Honma K, (2014) Simultaneous and long-term measurement of gene expression and neuronal activity from a brain slice. Protocol Exchange. doi:10.1038/protex.2014.010.
Brancaccio M, Enoki R, Mazuski C, Jones J, Evans J, Azzi A, (2014) Network-mediated encoding of circadian time: the suprachiasmatic nucleus (SCN) from genes to neurons to circuits, and back. J Neurosci. 34(46): 15192-15199.
Ono D, Kori H, Honma S, Daan S and Honma K, (2014) Cellular circadian rhythms in the suprachiasmatic nucleus: An oscillatory or a stochastic process? In: Honma K. ed. Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ. Press. pp. 25-36.
Enoki R, Honma S and Honma K, (2014) Imaging Circadian Calcium Rhythm in the Suprachiasmatic Nucleus In: Honma K. ed. Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ. Press. pp.37-49.
Honma S, Ono D and Honma K, (2014) Cellular oscillators in the suprachiasmatic nucleus for behavior rhythm expression in the mouse lacking CRYPTOCHROME. In: Honma K. ed. Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ. Press. pp.85-95.
Honma K, Ono D, Honma S and Tokuda I, (2014) Bout oscillators: Hypothetical circadian oscillators for activity bouts. In: Honma K. ed. Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ. Press. pp.87-111.
Tokuda I, Herzel H, Ono D, Honma S, Honma K, (2014) Oscillator network modeling of the suprachiasmatic nucleus in Cry1/Cry2 double deficient mice. In: Honma K. ed. Dynamics of Circadian Oscillation in the SCN, Hokkaido Univ. Press. 147-161.
Magota K, Hattori N, Manabe O, Naya M, Oyama-Manabe N, Shiga T, Kuge Y, Yamada S, Sakakibara M, Yoshinaga K, Tamaki N, (2014) Electrocardiographically gated 11C-hydroxyephedrine PET for the simultaneous assessment of cardiac sympathetic and contractile functions. Ann Nucl Med, Apr:28:3:187-95.
Yoshinaga K, Tomiyama Y, Manabe O, Kasai K, Katoh C, Magota K, Suzuki E, Nishijima KI, Kuge Y, Ito YM, Tamaki N, (2014) Prone-position acquisition of myocardial 123I-metaiodobenzylguanidine (MIBG) SPECT reveals regional uptake similar to that found using 11C-hydroxyephedrine PET/CT. Ann Nucl Med. 28(8): 761-769.
Naya M, Tamaki N, (2014) Imaging of myocardial oxidative metabolism in heart failure. Curr Cardiovasc Imaging Rep. 7: 9244.
Ishida Y, Yoshinaga K, Miyagawa M, Moroi M, Kondoh C, Kiso K, Kumita S, (2014) Recommendations for (18)F-fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis: Japanese Society of Nuclear Cardiology recommendations. Ann Nucl Med. 28:393-403.
Manabe O, Yoshinaga K, Ohira H, Sato T, Tsujino I, Yamada A, Oyama-Manabe N, Masuda A, Magota K, Nishimura M, Tamaki N, (2014) Right ventricular (18)F-FDG uptake is an important indicator for cardiac involvement in patients with suspected cardiac sarcoidosis. Ann Nucl Med. 28:656-63.
Okamoto S, Shiga T, Uchiyama Y, Manabe O, Kobayashi K, Yoshinaga K, Tamaki N, (2014) Lung uptake on I-131 therapy and short-term outcome in patients with lung metastasis from differentiated thyroid cancer. Ann Nucl Med, Feb;28(2):81-7.
Kuroda S, Kawabori M, Hirata K, Shiga T, Kashiwazaki D, Houkin K, Tamaki N, (2014) Clinical significance of STA-MCA double anastomosis for hemodynamic compromise in post-JET/COSS era. Acta Neurochir (Wien), Jan;156(1):77-83.
Kubo N, Tsuchiya K, Shiga T, Kojima S, Suzuki A, Ueno Y, Kobayashi K, Tamaki N, (2014) Collimator for variable sensitivity and spatial resolution without the need for exchange. IEEE Trans Nucl Sci. 61(5): 2489-2493.
Kubo N, Hirata K, Matsuzaki K, Morimoto Y, Takeuchi W, Hattori N, Shiga T, Kuge Y, Tamaki N, (2014) Evaluation of delineation of image details in semiconductor PET utilizing the normalized mutual information technique. Nucl Med Commun. 35(6): 677-682.
Tsuchiya K, Kinoshita R, Shimizu S, Nishioka K, Harada K, Nishikawa N, Suzuki R, Shirato H, (2014) Dosimetric comparison between intensity-modulated radiotherapy and standard wedged tangential technique for whole-breast radiotherapy in Asian women with relatively small breast volumes. Radiol Phys Technol, Jan;7(1):67-72.
Nishioka K, Shimizu S, Shinohara N, Ito YM, Abe T, Maruyama S, Kinoshita R, Harada K, Nishikawa N, Miyamoto N, Onimaru R, Shirato H, (2014) Prospective Phase II Study of Image-guided Local Boost Using a Real-time Tumor-tracking Radiotherapy (RTRT) System for Locally Advanced Bladder Cancer. Jpn J Clin Oncol, Jan;44(1):28-35.
Tanabe S, Myojin M, Shimizu S, Fujino M, Takahashi H, Shirato H, Ito YM, Ishikawa M, Hosokawa M, (2014) Dose-volume analysis for respiratory toxicity in intrathoracic esophageal cancer patients treated with definitive chemoradiotherapy using extended fields. J Radiat Res, Nov 1;54(6):1085-94.
Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S, (2014) The incidence of late neck recurrence in N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial chemoradiotherapy without prophylactic neck irradiation. Eur Arch Otorhinolaryngol, 271(10):2767-70.
Kikuchi Y, Oyama-Manabe N, Naya M, Manabe O, Tomiyama Y, Sasaki T, Katoh C, Kudo K, Tamaki N, Shirato H, (2014) Quantification of myocardial blood flow using dynamic 320-row multi-detector CT as compared with 15O-H 2O PET. Eur Radiol. 24:1547-1556.
Fujima N, Kudo K, Tsukahara A, Yoshida D, Sakashita T, Homma A, Tha KK, Shirato H, (2014) Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling: Comparison with dynamic contrast-enhanced MRI. J Magn Reson Imaging. 41(4):983-91.
Fujima N, Yoshida D, Sakashita T, Honma A, Tsukahara A, Tha KK, Kudo K, Shirato H, (2014) Intravoxel incoherent motion diffusion-weighted imaging in head and neck squamous cell carcinoma: assessment of perfusion-related parameters. Magn Reson Imaging. 32(10):1206-13.
Onodera S, Aoyama H, Tha KK, Hashimoto N, Toyomaki A, Terae S, Shirato H, (2014) The value of 4-month neurocognitive function as an endpoint in brain metastases trials. J Neurooncol. 120(2):311-9.
Yasuda M, Hatanaka T, Shirato H, Nishioka T, (2014) Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'- and 3'-UTRs. Biochem Biophys Res Commun. 447(4):638-43.
Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S, (2014) Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy. Br J Oral Maxillofac Surg. Apr;52(4):323-8.
Zhao Y, Watanabe A, Zhao S, Kobayashi T, Fukao K, Tanaka Y, Nakano T, Yoshida T, Takemoto H, Tamaki N, Kuge Y, (2014) Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: Molecular imaging with 14C-FDG and 99mTc-annexin A5. PLoS One, 9(2): e89338.
Fatema CN, Zhao S, Zhao Y, Yu W, Murakami M, Nishijima K, Kitagawa Y, Tamaki N, Kuge Y, (2014) Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative status after radiotherapy in human head and neck cancer xenograft using radiolabeled FMISO and FLT. BMC Cancer. 14(1), 692.
Yamauchi T, Saito H, Ito M, Shichinohe H, Houkin K, Kuroda S, (2014) Platelet lysate and granulocyte-colony stimulating factor serve safe and accelerated expansion of human bone marrow stromal cells for stroke therapy. Transl Stroke Res. Dec;5(6):701-10.

Coordinating Office, Future Drug Discovery and Medical Care Innovation Project
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