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Baudino L, Shinohara Y, Nimmerjahn F, Furukawa J, Nakata M, Martínez-Soria E, Petry F, Ravetch JV, Nishimura S, Izui S. (2008) Crucial role of aspartic acid at position 265 in the CH2 domain for murine IgG2a and IgG2b Fc-associated effector functions. J Immunol. 181(9), 6664-6669.
Baudino L, Nimmerjahn F, Shinohara Y, Furukawa J, Petry F, Verbeek JS, Nishimura S, Ravetch JV, Izui S. (2008) Impact of a three amino acid deletion in the CH2 domain of murine IgG1 on Fc-associated effector functions. J Immunol. 181(6), 4107-4112.
Mizutani Y, Kihara A, Chiba H, Tojo H, Igarashi Y, (2008) Synthesis of 2-hydroxy-ceramide by ceramide synthase family members: enzymatic basis for the preference of fatty acid chain length in cultured cell models. J. Lipid Res., 49, 2356-2364.
Yi M, Kohanawa M, Ozaki M, et al. (2008) Mutual modulation between interleukin-10 and interleukin-6 induced by Rhodococcus aurantiacus infection in mice. Microbes Infect. 10, 1450-1458.
Kouno T, Fujitani N, Mizuguchi M, et al. (2008) A novel b-defensin structure: a strategy of big defensin for a resistance by Gram-positive bacteria. Biochemistry., 47, 10611-10619.
Gao X-D, Moriyama S, Miura N, et al. (2008) Interaction between the C-termini of Alg13 and Alg14 mediate formation of the active UDP-N-acetylglucosamine transferase complex. J. Biol. Chem. 283, 32534-32541.
Shichinohe H, Kuroda S, Tsuji S, et al. (2008) Bone marrow stromal cells differentiate into neurons and promote axon elongation in spinal cord slice cultures: Their role in cell transplantation therapy for spinal cord injury. Neurorehabil Neural Repair. 22(5):447-57.
Yasuda K, Taguchi H, Sawamura Y, et al. (2008) Low-dose Craniospinal Irradiation and Ifosfamide, Cisplatin and Etoposide for Non-metastatic Embryonal Tumors in the Central Nervous System. Jap J Clin Oncol. 38(7):486-92.Epub.
Gao Y-G, Suzuki H, Itou H, et al. (2008) Structural and functional characterization of the LldR from Corynebacterium glutamicum: a transcriptional repressor involved in L-lactate and sugar utilization. Nucl. Acid Res. 36, 7110-7123.
Kitamura M, Okuyama M, Tanzawa F, et al. (2008) Structural and Functional Analysis of a Glycoside Hydrolase Family 97 Enzyme from Bacteroides thetaiotaomicron. J. Biol. Chem. 283, 36328-36337.
Watanabe M, Tanaka Y, Suenaga A, et al. (2008) Structural Basis for Multimeric Heme Complexation through a Specific Protein-Heme Interaction: the case of the third NEAT domain of IsdH from Staphylococcus aureus. J. Biol. Chem. 283, 28649-28659.
Tanaka Y, Sakamoto S, Kuroda M, et al. (2008) A Helical String of Alternately Connected Two Three-helix Bundles for the 1.1-Megadalton Cell Wall-Associated Adhesion Protein Ebh from Staphylococcus aureus. Structure, 16, 488-496.
Nonaka Y, Aizawa T, Akieda D, et al. (2008) Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions. Proteins, 72, 313-322.
Gao Y-G, Yao M, Tanaka I, (2008) Structure of protein PH0536 from Pyrococcus horikoshii at 1.7 A resolution reveals a novel assembly of an oligonucleotide/oligosaccharide-binding fold and an α-helical bundle. Proteins, 71, 503-508.
Itou H, Yao M, Watanabe N, et al. (2008) Crystal structure of the PH1932 protein, a unique archaeal ArsR type winged-HTH transcription factor from Pyrococcus horikoshii OT3. Proteins, 70, 1631-1634.
Zhang X, Nakashima T, Kakuta Y, et al. (2008) Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3. Protein Sci. 17, 136-145.
Kuroda M, Ito R, Tanaka Y, et al. (2008) Staphylococcus aureus Surface Protein SasG Contributes to Intercellular Autoaggregation of Staphylococcus aureus. Biochem. Biophys. Res. Commun. 377, 1102-1106.
Sakamoto S, Tanaka Y, Tanaka I, et al. (2008) Electron Microscopy and Computational Studies of Ebh, a Giant Cell-wall-associated Protein from Staphylococcus aureus. Biochem. Biophys. Res. Commun. 376, 261-266.
Kawamura T, Watanabe N, Tanaka I, (2008) Structure of mannosyl-3-phosphoglycerate phosphatase from Pyrococcus horikoshii. Acta Cryst. D64, 1267-1276.
Okada U, Kondo K, Hayashi T, et al. (2008) Structural and functional analysis of the TetR-family transcriptional regulator SCO0332 from Streptomyces coelicolor. Acta Cryst. D64, 198-205.
Begum P, Sakai N, Hayashi T, et al. (2008) Crystal Structure of SCO6571 from Streptomyces coelicolor A3(2). Protein & Peptide Letters, 15, 709-712.
Hu S-Q, Gao Y-G, Tajima K, et al. (2008) Purification, Crystallization and Preliminary X-Ray Studies of AxCesD Required for Efficient Cellulose Biosynthesis in Acetobacter xylinum. Protein & Peptide Letters, 15, 115-117.
Averbeck N, Gao X-D, Nishimura S.-I., et al. (2008) Alg13, the catalytic subunit of the ER UDP-GlcNAc glycosyltransferase, is a target for proteasomal degradation. Mol. Biol. Cell. 19, 2169-2178
Sasaki T, Iwasaki N, Kohno K, et al. (2008) Magnetic nanoprticles for improving cell invasion in tissue engineering. J. Biomed. Mater. Res. A 86, 969-978.
Kasahara Y, Iwasaki N, Yamane S, et al. (2008) Development of mature cartilage constructs using novel three-dimensional porous scaffolds for enhanced repair of osteochondral defects. J. Biomed. Mater. Res. A. 86A, 127-136.
Maeda T, and Nishimura S.-I. (2008) FRET-based direct and continuous monitoring of human fucosyltransferases activity: Efficient synthesis of versatile GDP-L-fucose derivatives from abundant D-galactose. Chem. Eur. J. 14, 478 - 487.
Ikeda M, Kihara A, Denpoh A, et al. (2008) The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry. Mol. Biol. Cell, 19, 1922-31.
Nakagawa H, Ohira M, Hayashi S, et al. (2008) Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system. Cancer Lett. 270, 295-301.
Furukawa J-I, Shinohara Y, Kuramoto H, et al. (2008) A comprehensive approach to structural and functional glycomics based on chemoselective glycoblotting and sequential tag conversion. Anal. Chem. 80, 1094-1101.
Miura Y, Hato M, Shinohara Y, et al. (2008) BlotGlycoABCTM: An integrated glycoblotting technique for rapid and large-scale clinical glycomics. Mol. Cell. Proteomics 7, 370-377.
Kyan A, Kamimura N, Hagisawa S, et al. (2008) Positive expression of N-acetylglucosaminyltransferase-V (GnT-V) and beta1-6 branching N-linked oligosaccharides in human testicular germ cells diminish during malignant transformation and progression. Int. J. Oncol. 32, 129-134.
Fujimura T, Shinohara Y, Tissot B, et al. (2008) Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects. Intl. J. Cancer 122, 39-49.
Nakahara T, Hashimoto R, Nakagawa H, et al. (2008) Glycoconjugate Data Bank:Structures---an annotated glycan structure database and N-glycan primary structure verification service. Nucleic Acids Res. 36, D368-371.
Kumeta H, Ogura K, Adachi S, et al. (2008) The NMR structure of the NIPP1 FHA domain. J. Biomol. NMR. 40, 219-24.
Fujioka Y, Noda N, Fujii K,et al. (2008) In vitro reconstitution of plant ATG8 and ATG12 conjugation systems essential for autophagy. J. Biol. Chem. 283, 1921-8.
Noda Y, Horikawa S, Kanda E, et al. (2008) Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. J Cell Biol. 182, 587-601.
Park H, Pack C, Kinjo M,et al. (2008) In Vivo Quantitative Analysis of PKA Subunit Interaction and cAMP level by Dual Color Fluorescence Cross Correlation Spectroscopy. Mol Cell. 26, 87-92.
Nakabayashi T, Nagao I, Kinjo M, et al. (2008) Stress-induced environmental changes in a single cell as revealed by fluorescence lifetime imaging. Photochem Photobiol Sci. 7, 671-674.
Nakabayashi T, Wang HP, Kinjo M, et al. (2008) Application of fluorescence lifetime imaging of enhanced green fluorescent protein to intracellular pH measurements. Photochem Photobiol Sci. 7, 668-670.
Aoki Y, Nagao I, Saito D, et al. (2008) Temporal and spatial localization of three germline-specific proteins in medaka. Dev Dyn. 237, 800-807.
Nagaya H, Tamura T, Higa-Nishiyama A, et al. (2008) Regulated motion of glycoproteins revealed by direct visualization of a single cargo in the endoplasmic reticulum. J Cell Biol. 180, 129-143.
Nagao I, Aoki Y, Tanaka M, et al. (2008) Analysis of the molecular dynamics of medaka nuage proteins by fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. FEBS J. 275, 341-349.
Baba K, Ono D, Honma S, et al. (2008) A TTX sensitive local circuit is involved in the expression of PK2 and BDNF circadian rhythms in the mouse suprachiasmatic nucleus. Eur.J.Neurosci. 27,909-916.
Honma S, Inagaki N, Ono D,et al. (2008) Clock mechanisms for seasonal adaptation: Morning and evening oscillators in the suprachiasmatic nucleus. Sleep Biol.Rhythms 6, 84-90.
Yamanaka Y, Honma S, et al. (2008) Scheduled exposures to a novel environment with a running-wheel differentially accelerate re-entrainment of mice peripheral clocks to new light-dark cycles. Genes Cells 13, 497-507.
Nishide S, Honma S and Honma K. (2008) The circadian pacemaker in the cultured suprachiasmatic nucleus from pup mice is highly sensitive to external perturbation. Eur J Neurosci 27, 2686-2690.
Nakashima A, Kawamoto T, Honda, KK,et al. (2008) Dec1 modulates circadian phase of clock gene expression. Mol.Cell.Biol. 28, 4080-4092.
Kononenko NI, Honma S, Dudek FE,et al. (2008) On the role of calcium and potassium currents in circadian modulation of firing rate in rat suprachiasmatic nucleus neurons: Multielectrode dish analysis. Neurosci Res. 62, 51-57.
Kwon HJ, Akimoto H, Ohmiya Y, et al. (2008) Gene expression profile of rabbit cartilage by expressed sequence tag analysis. Gene. 424, 147-152.
Tanabe Y, Yasuda K, Azuma C, et al. (2008) Biological responses of novel high-toughness double network hydrogels in muscle and the subcutaneous tissues. J Mater Sci-Mater M. 19, 1379-1387.
Suzuki-Ogoh C, Wu C, Ohmiya Y (2008) C-terminal region of the active domain enhances enzymatic activity in dinoflagellate luciferase. Photochem Photobiol Sci. 7, 208-11.
Noguchi T, Ikeda M, Ohmiya Y, et al. (2008) Simultaneous monitoring of independent gene expression patterns in two types of cocultured fibroblasts with different color-emitting luciferases. BMC Biotechnol. 8, 40.
Zhao S, Kuge Y, Kohanawa M, et al. (2008) Usefulness of 11C-Methionine for Differentiating Tumors from Granulomas in Experimental Rat Models: a Comparison with 18F-FDG and 18F-FLT. J Nucl Med. 49, 135-141.
Zhao Y, Kuge Y, Zhao S, et al. (2008) Prolonged High-Fat Feeding Enhances Aortic 18F-FDG and 99mTc-annexin A5 Uptake in ApoE-/- and Wild-Type C57BL/6J mice. J Nucl Med. 49, 1707-1714.
Ishino S, Mukai T, Kuge Y, et al. (2008) Targeting of lectin-like oxidized low - density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque. J Nucl Med. 49, 1677-1685.
Kuge Y, Kume N, Ishino S, et al. (2008) Prominent lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) expression in atherosclerotic lesions is associated with tissue factor expression and apoptosis in hypercholesterolemic rabbits. Biol Pharm Bull. 31, 1475-82.
Hokari M, Kuroda S, Shichinohe H, et al. (2008) Bone marrow stromal cells protect and repair damaged neurons through multiple mechanisms. J Neurosci Res. 86, 1024-1035.
Onimaru R, Fujino M, Yamazaki K, et al. (2008) Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy. Int J Radiat Oncol Biol Phys. 70, 374-81.
Nishioka S, Nishioka T, Kawahara M, et al. (2008) Exhale fluctuation in respiratory-gated radiotherapy of the lung: a pitfall of respiratory gating shown in a synchronized internal/external marker recording study. Radiother Oncol. 86, 69-76.
Ruan D, Fessler JA, Balter JM, et al. (2008) Inference of hysteretic respiratory tumor motion from external surrogates: a state augmentation approach. Phys Med Biol. 53, 2923-36.
Katoh N, Onimaru R, Sakuhara Y, et al. (2008) Real-time tumor-tracking radiotherapy for adrenal tumors. Radiother Oncol. 87, 418-24.
Imura M, Yamazaki K, Kubota KC, et al. (2008) Histopathologic Consideration of Fiducial Gold Markers Inserted for Real-Time Tumor-Tracking Radiotherapy Against Lung Cancer. Int J Radiat Oncol Biol Phys. 70, 382-4.

Coordinating Office, Future Drug Discovery and Medical Care Innovation Project
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