Top > Project > List of achievements


Tsukamoto T, Morita K, Naya M, Inubushi M, Katoh C, Nishijima K, Kuge Y, Okamoto H, Tsutsui H, Tamaki N, (2007) Decreased myocardial beta-adrenergic receptor density in relation to increased sympathetic tone in patients with nonischemic cardiomyopathy. J Nucl Med. 48:1777-82.
Kitago Y, Karita S, Watanabe N, et al. (2007) Structure of Cel44A, a Glycoside Hydrolase Family 44 Endoglucanase from Clostridium thermocellum. J. Biol. Chem. 282, 35703-35711.
Tanaka Y, Morikawa K, Ohki Y, et al. (2007) Structural and Mutational Analyses of Drp35 from Staphylococcus aureus: a possible mechanism for its lactonase activity. J. Biol. Chem. 282, 5770-5780.
Iyaguchi D, Yao M, Watanabe N, et al. (2007) DNA Recognition Mechanism of the ONECUT Homeodomain of Transcription Factor HNF-6. Structure, 15, 75-83.
Tanaka Y, Kuroda M, Yasutake Y, et al. (2007) Crystal structure analysis reveals a novel forkhead-associated domain of ESAT-6 secretion system C protein in Staphylococcus aureus. Proteins, 69, 659-664.
Tanaka Y, Sasaki T, Kumagai I, et al. (2007) Molecular properties of two proteins homologous to PduO-type ATP: cob(I)alamin adenosyltransferase from Sulfolobus tokodaii, Proteins. 68, 446-457.
Gao Y-G, Yao M, Itou H, et al. (2007) The structures of transcription factor CGL2947 from Corynebacterium glutamicum in two crystal forms: A novel homodimer assembling and the implication for effector-binding mode. Protein Science, 16, 1878-1886.
Daisuke I, Yao M, Watanabe N, et al. (2007) Crystallization and Preliminary X-Ray Studies of the Unliganded Wild-Type Bovine Thrombin. Protein & Peptide Letters, 14, 923-924.
Kurogochi M, Amano M, Fumoto M, et al. (2007) Reverse glycoblotting allows rapid enrichment glycoproteomics of biopharmaceuticals and disease-related biomarkers. Angew. Chem. Int. Ed., 46, 8808-8813.
Kita Y, Miura Y, Furukawa J.-i., et al. (2007) Quantitative glycomics of human whole serum glycoproteins based on the standardized protocol for liberating N-glycans. Mol. Cell. Proteom., 6, 1437-1445.
Majima T, Irie T, Sawaguchi N, et al. (2007) Chitosan-based hyaluronan hybrid polymer fibre scaffold for ligament and tendon tissue engineering. Proc. Inst. Mech. Eng. Part H-J. Eng. Med. 221, 537-546.
Shimawaki K, Fujisawa Y, Sato F, et al. (2007) Highly efficient synthesis of versatile proteoglycan core structures from 1,6-anhydro-β-lactose as a key starting material. Angew. Chem. Int. Ed. 46, 3074-3079.
Andre S, Sanchez-Ruderisch H, Nakagawa H, et al. (2007) Tumor Suppressor p16INK4a: Modulator of Glycomic Profile and Galectin-1 Expression to Increase Susceptibility to Carbohydrate-Dependent Induction of Anoikis in Pancreatic Carcinoma Cells. FEBS J. 274, 3233-3256.
Uemura S, Feng F., Kume M, et al. (2007) Cell Growth Arrest by Sialic Acid Clusters in Ganglioside GM3 Mimetic Polymers. Glycobiology 17, 568-577.
Kabayama K, Sato T, Saito K, et al. (2007) Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance. Proc Natl Acad Sci U S A. 104, 13678-13683.
Iwaki S, Sano T, Takagi T, et al. (2007) Intracellular trafficking pathway of yeast long-chain base kinase Lcb4, from its sythesis to its degradation. J. Biol. Chem. 282, 28485-92.
Noguchi M, Suzuki T, Kabayama K, et al. (2007) GM3 synthase gene is a novel biomarker for histological classification and drug sensitivity against epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Cancer Science. 98, 1625-32.
Kasahara K, Nakayama Y, Kihara A, et al. (2007) Rapid trafficking of c-Src, a non-palmitoylated Src-family kinase, between the plasma membrane and late endosomes/ lysosomes. Exp. Cell Res. 313, 2651-66.
Nodai A, Machida T, Izumi S, et al. (2007) Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. Life Sci. 80, 1768-76.
Date T, Mitsutake S, Igarashi Y. (2007) Ceramide kinase expression is altered during macrophage-like cell differentiation of the leukemia cell line HL-60. In Vitro Cell Dev Biol Anim 43, 321-323.
Mitsutake S, Yokose U, Kato M, et al. (2007) The generation and behavioral analysis of ceramide kinase-null mice, indicating a function in cerebellar Purkinje cells. Biochem Biophys Res Commun. 363, 519-524.
Kumada H, Mitsutake M, Igarashi Y, (2007) Kinetics of the ceramide kinase inhibitor K1, a suppressor of mast cell activation. Biosci. Biotech. Biochem. 71, 2581-2584.
Mitsutake M, Igarashi Y. (2007) Transbilayer movement of ceramide in the plasma membrane of live cells. Biochem Biophys Res Commun. 359, 622-7.
Anada Y, Igarashi Y, Kihara A. (2007) The immunomodulator FTY720 is phosphorylated and released from platelets. Eur J Pharm. 568, 106-111.
Kihara A, Mitsutake S, Mizutani Y, et al. (2007) Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog. Lipid Res. 46, 126-144.
Ito K, Anada Y, Tani M, et al. (2007) Lack of sphingosine 1-phosphate (S1P)-degrading enzymes in erythrocytes, a potential major source of plasma S1P in addition to platelets. Biochem Biophys Res Commun. 357, 212-217.
Itoh N, Sakaue S, Nakagawa H, et al. (2007) Increased a1,6-fucosylation of N-glycan in serum glycoprotein of db/db mice and humans with type 2 diabetes. Am. J. Physiol.-Endocrinol. Metab. 293, E1069-77.
Kitatsuji C, Kurogochi M, Nishimura S.-I., et al. (2007) Molecular Basis of Guanine Nucleotide Dissociation Inhibitor Activity of Human Neuroglobin by Chemical Cross-Linking and Mass Spectrometry. J. Mol. Biol. 368, 150-160.
Kudo T, Nakagawa H, Takahashi M, et al. (2007) N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma. Molecular Cancer 6, 32.
Shimaoka H, Kuramoto H, Furukawa J, et al. (2007) One-Pot Solid-Phase Glycoblotting and Probing by Transoximization for High-Throughput Glycomics and Glycoproteomics. Chem. Eur. J. 13, 1664-1673.
Miura Y, Shinohara Y, Furukawa J.-I., et al. (2007) Rapid and Simple Solid-Phase Esterification of Sialic Acid Residues for Quantitative Glycomics by Mass Spectrometry. Chem. Eur. J. 13, 4797- 4804.
Nishida K, Horiuchi M, Noda N.N., et al. (2007) Crystallization and preliminary crystallographic analysis of the Tob-hCaf1 complex. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63, 1061-1063.
Takahasi K, Yoneyama M, Nishihori T, et al. (2007) Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses. Mol. Cell 29, 428-40.
Hanada T, Noda N, Satomi Y, et al. (2007) The ATG12-ATG5 conjugate has a novel e3-like activity for protein lipidation in autophagy. J. Biol. Chem. 282, 37298-302.
Kobashigawa Y, Naito M, Inagaki F, (2007) An efficient method for protein phosphorylation using the artificially introduced of cognate-binding modules into kinases and substrates. J .Biotechnol. 131, 458-65.
Saio T, Kumeta H, Ogura K, et al. (2007) Domain II in the Iron-Sulfur Cluster Transfer Process as Revealed by NMRJun. J. Biochem. (Tokyo). 142, 113-121.
Yamaguti M, Noda N, Fujioka Y, et al. (2007) Crystallization and preliminary X-ray analysis of Atg10. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63(Pt 5), 443-5.
Kumeta H, Ogura K, Asayama M, et al. (2007) The NMR structure of the domain II of a chloroplastic NifU-like protein OsNifU1A. J. Biomol. NMR. 38, 161-4.
Kobashigawa Y, Sakai M, Naito N, et al. (2007) Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Nat. Struct. Mol. Biol. 14, 503-10.
Adachi W, Noda N, Fujioka Y, et al. (2007) Crystallization of Saccharomyces cerevisiae Aminopeptidase 1, the major cargo protein of the Cvt pathway. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 63(Pt3), 200-3.
Yamada Y, Noda N, Hanada T, et al. (2007) The crystal structure of ATG3, an autophagy-related E2 enzyme that mediates ATG8 lipidation. J. Biol. Chem. 282, 8036-43.
Honbou K, Minakami R, Yuzawa S, et al. (2007) Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J. 26, 1176-86.
Fujii F, Kinjo M, (2007) Detection of antigen protein by using fluorescence cross-correlation spectroscopy and quantum- dot-labeled antibodies. Chembiochem. 8, 2199-2203.
Nomura Y, Nakamura T, Feng Z, et al. (2007) Direct quantification of gene expression using fluorescence correlation spectroscopy. Curr Pharm Biotechnol. 8, 286-290.
Pieper T, Markova S, Kinjo M, et al. (2007) Effect of cholesterol on diffusion in surfactant bilayers. J Chem Phys. 127, 165102.
Jin T, Fujii F, Yamada E, et al. (2007) Preparation and characterization of thiacalix[4]arene coated water-soluble CdSe/ZnS quantum dots as a fluorescent probe for Cu2+ ions. Comb Chem High Throughput Screen. 10, 473-479.
Fujii F, Horiuchi M, Ueno M, et al. (2007) Detection of prion protein immune complex for bovine spongiform encephalopathy diagnosis using fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy. Anal Biochem. 370, 131-141.
Takahashi Y, Okamoto Y, Popiel HA, et al. (2007) Detection of polyglutamine protein oligomers in cells by fluorescence correlation spectroscopy. J Biol Chem. 282, 24039-24048.
Shimizu M, Sasaki S, Kinjo M, (2007) Triplet fraction buildup effect of the DNA-YOYO complex studied with fluorescence correlation spectroscopy. Anal Biochem. 366, 87-92.
Kii H, Takagi T, Sasaki A, et al. (2007) DNA microstructure based on self-assembly of 4-sticky-end Holliday junctions in aqueous solution. J Nanosci Nanotechnol. 7, 726-729.
Muto H, Watahiki MK, Nakamoto D, et al. (2007) Specificity and similarity of functions of the Aux/IAA genes in auxin signaling of Arabidopsis revealed by promoter-exchange experiments among MSG2/IAA19, AXR2/IAA7, and SLR/IAA14. Plant Physiol. 144, 187-196.
Araki Y, Kawano T, Taru H, et al. (2007) The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 26, 1475-1486.
Mikuni S, Pack C, Tamura M, et al. (2007) Diffusion analysis of glucocorticoid receptor and antagonist effect in living cell nucleus. Exp Mol Pathol. 82, 163-168.
Mikuni S, Tamura M, Kinjo M. (2007) Analysis of intranuclear binding process of glucocorticoid receptor using fluorescence correlation spectroscopy. FEBS Lett. 581, 389-393.
Wu C, Suzuki-Ogoh C and Ohmiya Y, (2007) A dual-reporter assey using two secreted luciferase genes. Biotechniques 42, 290-292.
Wu C, Kawasaki K, Ogawa Y, et al. (2007) Preparation of biotinylated Cypridina luciferase and its use in bioluminescent enzyme immunoassay. Anal Chem 79,1634-1638.
Abe H, Honma S and Honma K, (2007) Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R607-R615
Ando Y, Niwa K, Yamada N, et al. (2007) Firefly bioluminescence quantum yield and colour change by pH-sensitive green emission. Nat Photonics 2,44-47.
Ando Y, Niwa K, Yamada N, et al. (2007) Development of a quantitative bio/chemiluminescence spectrometer determining quantum yields: Re-examination of the aqueous luminol chemiluminescence standard. Photochem Photobiol. 83, 1205-1210.
Kanjou N, Nagao A, Ohmiya Y, et al. (2007) Yeast mutant with efficient secretion identified by a novel secretory reporter, Cluc. Biochem Biophys Res Commun. 358 , 429-434.
Hoshino H, Nakajima Y, Ohmiya Y, (2007) Single-cell imaging with fluorescent protein excited by luciferin-luciferase reaction. Nat Methods 8 , 637-639.
Inagaki N, Honma S, Ono D, et al. (2007) Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. Proc. Natl. Acad. Sci. U.S.A. 104, 7664-7669.
Hayasaka N, Yaita T, Kuwak T, et al. (2007) Optimization of dosing schedule of daily inhalant Dexamethasone to minimize phase-shifting of clock gene expression rhythm in the lungs of the asthma mouse model. Endocrinology 148, 3316-3326.
Zhao S, Kuge Y, Kohanawa M, et al. (2007) Extensive FDG uptake and its modification with corticosteroid in a granuloma rat model: an experimental study for differentiating granuloma from tumors. Eur J Nucl Med Mol Imaging. 34, 2096-2105.
Kanegae K, Nakano I, Kimura K, et al. (2007) Comparison of MET-PET and FDG-PET for differentiation between benign lesions and lung cancer in pneumoconiosis. Ann Nucl Med. 21, 331-337.
Seki K, Nishijima K, Kuge Y, et al. (2007) A novel and efficient synthesis of [2-11C]5-fluorouracil for prognosis of cancer chemotherapy. J Pharm Pharmaceut Sci. 10, 181-185.
Zhao Y, Kuge Y, Zhao S, et al. (2007) Comparison of 99mTc-annexin A5 with 18F-FDG for the detection of atherosclerosis in ApoE-/- mice. Eur J Nucl Med Mol Imagin. 34, 1747-1755.
Ishino S, Kuge Y, Takai N, et al. (2007) 99mTc-Annexin A5 for noninvasive characterization of atherosclerotic lesions: imaging and histological studies in myocardial infarction-prone Watanabe heritable hyperlipidemic rabbits. Eur J Nucl Med Mol Imaging. 34, 889-899.
Ishino S, Mukai T, Kume N, et al. (2007) Lectin-like oxidized LDL receptor-1 (LOX-1) expression is associated with atherosclerotic plaque instability-analysis in hypercholesterolemic rabbits. Atherosclerosis. 195, 48-56.
Kuge Y, Takai N, Ishino S, et al. (2007) Distribution Profiles of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP), Matrix Metalloproteinase-2 (MMP-2) and Cyclooxygenase-2 (Cox-2) in Rabbit Atherosclerosis: Comparison with Plaque Instability Analysis. Biol Pharm Bull. 30, 1634-1640.
Shichinohe H, Kuroda S, Yano S, et al. (2007) Role of SDF-1/CXCR4 system in survival and migration of bone marrow stromal cells after transplantation into mice cerebral infarct. Brain Res. 1183, 138-147.
Seino T and Takahashi I, (2007) CdTe Detector Characteristics at 30 C and 35C When Using the Periodic Bias Reset Technique. IEEE Trans. Nucl. Sci. 54, 777-781.
Kinoshita R, Shimizu S, Taguchi H, et al. (2007) Three-dimensional intrafractional motion of breast during tangential breast irradiation monitored with high-sampling frequency using a real-time tumor-tracking radiotherapy system. Int J Radiat Oncol Biol Phys. 70, 931-4.
Aoyama H, Tago M, Kato N, et al. (2007) Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone. Int J Radiat Oncol Biol Phys. 68, 1388-1395.
Shirato H, Shimizu S, Kitamura K, et al. (2007) Organ motion in image-guided radiotherapy: lessons from real-time tumor-tracking radiotherapy. Int J Clin Oncol. 12, 8-16.
Wu H, Sandison G, Zhao L, et al. (2007) Correlation between parameters describing tumour motion and its location in the lungs. Australas Phys Eng Sci Med 30, 341-4.
Wu H, Sharp GC, Zhao Q, et al. (2007) Statistical analysis and correlation discovery of tumor respiratory motion. Phys Med Biol. 52, 4761-74.
Seppenwoolde Y, Berbeco RI, Nishioka S, et al. (2007) Accuracy of tumor motion compensation algorithm from a robotic respiratory tracking system: a simulation study. Med Phys. 34, 2774-84.
Kanoulas E, Aslam JA, Sharp GC, et al. (2007) Derivation of the tumor position from external respiratory surrogates with periodical updating of the internal/external correlation. Phys Med Biol. 52, 5443-56.
Taguchi H, Sakuhara Y, Hige S, et al. (2007) Intercepting radiotherapy using a real-time tumor-tracking radiotherapy system for highly selected patients with hepatocellular carcinoma unresectable with other modalities. Int J Radiat Oncol Biol Phys. 69, 376-80.
Nishioka T, Yasuda M, Tsutsumi K, et al. (2007) Matrix metalloproteinases: up-regulated in subclones that survived 10-Gy irradiation. Radiat Med. 25, 430-1.
Kamiyama T, Nakanishi K, Yokoo H, et al. (2007) Efficacy of preoperative radiotherapy to portal vein tumor thrombus in the main trunk or first branch in patients with hepatocellular carcinoma. Int J Clin Oncol. 12, 363-8.
Murphy MJ, Balter J, Balter S, et al. (2007) The management of imaging dose during image-guided radiotherapy: report of the AAPM Task Group 75. Med Phys. 34, 4041-63.
Ionascu D, Jiang SB, Nishioka S, et al. (2007) Internal-external correlation investigations of respiratory induced motion of lung tumors. Med Phys. 34, 3893-903.
Ren Q, Nishioka S, Shirato H, et al. (2007) Adaptive prediction of respiratory motion for motion compensation radiotherapy. Phys Med Biol. 52, 6651-61.
Yokouchi H, Chamoto K, Wakita D, et al. (2007) Combination tumor immunotherapy with radiotherapy and Th1 cell therapy against murine lung carcinoma. Clin Exp Metastasis 24, 533-40.
Onishi H, Shirato H, Nagata Y, et al. (2007) Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study. J Thorac. Oncol. 2(7 Suppl 3), S94-100.

Coordinating Office, Future Drug Discovery and Medical Care Innovation Project
Kita 21, Nishi 10, Kita-ku, Sapporo, Hokkaido 001-0021, Japan
Tel: +81-(0)11-706-9188 Fax: +81-(0)11-706-9190

copyright 2007 hokkaido university.

| Contact info for interviews | Contact us | Link |
| Handling of Information | Sitemap |